Published on 2024/07/09                                                                                                             Research powered by Mightex’s Polygon1000     

So Chung Him, Zhang Ting, Wang Qin, Tse, Dennis Y & Feng Pan , Biophysical effects of focused and defocused image stimuli on dopaminergic amacrine cells and AII amacrine cells in the mouse retina. The Hong Kong Polytechnic University, (2024). 

Located in the inner nuclear layer of retinas, dopaminergic amacrine cells (DACs) serve as an inhibitory network that modulates signal processing. AII amacrine cells (AII ACs) connect with most subtypes of cone bipolar cells, and changes in AII receptive field properties may dramatically influence signaling in the retinal output.

To explore the possibility that DACs and AII ACs in retinas play a role in detecting focused and defocused signals and driving eyeball growth, it’s important to establish whether these amacrine cells recognize different patterns of stimuli.

The Mightex Polygon1000 system enables the production of annulus/spots at 525 nm wavelength. Polyscan3 software provides stimulation in the form of spot sizes ranging from 30 to 180um in diameter. Annulus is defined as the difference between the outer and inner diameters, from 180-30, 180-60, 180-90, and 180-120, OD – ID in um. The stimuli are presented sequentially according to the diagram.